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08/28/2018

Cancer Discovery, 2018, 8(10):1250-1257.

SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study.

Antoni Ribas, Theresa Medina, Shivaani Kummar, Asim Amin, Anusha Kalbasi, Joseph J. Drabick, Minal Barve, Gregory A. Daniels, Deborah J. Wong, Emmett V. Schmidt, Albert F. Candia, Robert L. Coffman, Abraham C.F. Leung, and Robert S. Janssen.

08/28/2018

Cancer Discovery, 2018, 8(10):1258-1269.

In situ vaccination with a TLR 9 agonist and local low dose radiation induces systemic responses in untreated indolent lymphoma.

Matthew J. Frank, Patrick M Reagan, Nancy L Bartlett, Leo I Gordon, Jonathan W Friedberg, Debra K. Czerwinski, Steven R. Long, Richard T. Hoppe, Robert Janssen, Albert F Candia, Robert L Coffman, and Ronald Levy.

06/26/2018

Cancer Research, 2018, 78(17):4943-4956.

Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay.

Marilena Gallotta, Hikmat Assi, Émilie Degagné, Shravan Kumar Kannan, Robert L. Coffman and Cristiana Guiducci.

09/21/2017

JCI Insight, 2017, 2(18): e93397.

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

Fumi Sato-Kaneko, Shiyin Yao, Alast Ahmadi, Shannon S. Zhang, Tadashi Hosoya, Megan M. Kaneda, Judith A. Varner, Minya Pu, Karen S. Messer, Cristiana Guiducci, Robert L. Coffman, Kazutaka Kitaura, Takaji Matsutani, Ryuji Suzuki, Dennis A. Carson, Tomoko Hayashi, and Ezra E.W. Cohen.

11/01/2016

PNAS, 2016;113(46):E7240-E7249.

Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells

Shu Wang, Jose Campos, Marilena Gallotta, Mei Gong, Chad Crain, Edwina Naik, Robert L. Coffman, and Cristiana Guiducci

04/13/2016

Bioconjugate Chemistry, 2016, 27, 1293−1304, DOI: 10.1021/acs.bioconjchem.6b00107

Optimization, Production, and Characterization of a CpGOligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen

Bob Milley, Radwan Kiwan, Gary S. Ott, Carlo Calacsan, Melissa Kachura, John D. Campbell, Holger Kanzler, and Robert L. Coffman

01/04/2016

The Journal of Immunology, 2016; 196:284-297; Prepublished online 25 November 2015; doi: 10.4049/jimmunol.1501903

A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys

Melissa A. Kachura, Colin Hickle, Sariah A. Kell, Atul Sathe, Carlo Calacsan, Radwan Kiwan, Brian Hall, Robert Milley, Gary Ott, Robert L. Coffman, Holger Kanzler and John D. Campbell

01/06/2015

Cell. Immunol., 2004; 229(2):93-105.

Polymyxin B enhances ISS-mediated immune responses across multiple species.

Marshall, J.D., D. Higgins, C. Abbate, P. Yee, G. Teshima, G. Ott, T. Dela Cruz, D. Passmore, K.L. Fearon, S. Tuck, and G. Van Nest.

01/06/2015

J. Exp. Med., 2008; 205(2):315-22

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.

Cristiana Guiducci, Cristina Ghirelli, Marie-Annick Marloie-Provost, Tracy Matray, Robert L. Coffman, Yong-Jun Liu, Franck J. Barrat, and Vassili Soumelis.

01/06/2015

J. Allergy Clin. Immunol., 2000; 106:124-134.

Conjugation of Immunostimulatory DNA to the Short Ragweed Allergen Amb a 1 Enhances its Immunogenicity and Reduces its Allergenicity.

Tighe, H., K. Takabayashi, D. Schwartz, G. Van Nest, S. Tuck, J.J. Eiden, A. Kagey-Sobotka, P.S. Creticos, L.M. Lichtenstein, H.L. Spiegelberg, and E. Raz.