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04/13/2016

Bioconjugate Chemistry, 2016, 27, 1293−1304, DOI: 10.1021/acs.bioconjchem.6b00107

Optimization, Production, and Characterization of a CpGOligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen

Bob Milley, Radwan Kiwan, Gary S. Ott, Carlo Calacsan, Melissa Kachura, John D. Campbell, Holger Kanzler, and Robert L. Coffman

01/04/2016

The Journal of Immunology, 2016; 196:284-297; Prepublished online 25 November 2015; doi: 10.4049/jimmunol.1501903

A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys

Melissa A. Kachura, Colin Hickle, Sariah A. Kell, Atul Sathe, Carlo Calacsan, Radwan Kiwan, Brian Hall, Robert Milley, Gary Ott, Robert L. Coffman, Holger Kanzler and John D. Campbell

01/06/2015

Cell. Immunol., 2004; 229(2):93-105.

Polymyxin B enhances ISS-mediated immune responses across multiple species.

Marshall, J.D., D. Higgins, C. Abbate, P. Yee, G. Teshima, G. Ott, T. Dela Cruz, D. Passmore, K.L. Fearon, S. Tuck, and G. Van Nest.

01/06/2015

J. Exp. Med., 2008; 205(2):315-22

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.

Cristiana Guiducci, Cristina Ghirelli, Marie-Annick Marloie-Provost, Tracy Matray, Robert L. Coffman, Yong-Jun Liu, Franck J. Barrat, and Vassili Soumelis.

01/06/2015

J. Allergy Clin. Immunol., 2000; 106:124-134.

Conjugation of Immunostimulatory DNA to the Short Ragweed Allergen Amb a 1 Enhances its Immunogenicity and Reduces its Allergenicity.

Tighe, H., K. Takabayashi, D. Schwartz, G. Van Nest, S. Tuck, J.J. Eiden, A. Kagey-Sobotka, P.S. Creticos, L.M. Lichtenstein, H.L. Spiegelberg, and E. Raz.

01/06/2015

J. Allergy Clin. Immunol., 2001; 108:191-197.

Immunostimulatory Sequence DNA Linked to the Amb a 1 Allergen Promotes Th1 Cytokine Expression While Downregulating Th2 Cytokine Expression in PBMCs from Human Patients with Ragweed Allergy.

Marshall, J.D., S. Abtahi, J.J. Eiden, S. Tuck, R. Milley, F. Haycock, M.J. Reid, A. Kagey-Sobotka, P.S. Creticos, L.M. Lichtenstein, and G. Van Nest.

01/06/2015

J. Allergy Clin. Immunol., 2004; 113(6):1144-1151.

Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA.

Simons, F.E., Y. Shikishima, G. Van Nest, J.J. Eiden, and K.T. HayGlass.

01/06/2015

BioDrugs, 2006; 6(20):335-340(6).

Evolving strategies for the prevention of influenza infection: potential for multistrain targeting.

Livingston BD, Higgins D, Van Nest G.

01/06/2015

Vaccine, 2003; 21(19-20): 2461-2467.

A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant.

Halperin, S.A., G. Van Nest, B. Smith, S. Abtahi, H. Whiley, and J.J. Eiden.

01/06/2015

Vaccine, 2006; 24(1): 20-26.

Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults.

Scott A. Halperin, Simon Dobson, Shelly McNeil, Joanne M. Langley, Bruce Smith, Robyn McCall-Sani, Dan Levitt, Gary Van Nest, Daniel Gennevois, Joseph J. Eiden.