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J. Virol., 2002; 76: 11387-11396.

Use of Immunostimulatory Sequence-Containing Oligonucleotides as Topical Therapy for Genital Herpes Simplex Virus Type 2 Infection.

Pyles, R.B., D. Higgins, C. Chalk, A. Zalar, J. Eiden, C. Brown, G. Van Nest, and L.R. Stanberry.


J. Leukoc. Biol., 2003; 73(6):781-792.

Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions.

Marshall, J.D., K. Fearon, C. Abbate, S. Subramanian, P. Yee, J. Gregorio, R.L. Coffman, and G. Van Nest.


Eur. J. Immunol., 2003; 33: 2114-2122.

A minimal human immunostimulatory CpG motif that potently induces IFN-gamma and IFN-alpha production.

Fearon, K., J.D. Marshall, C. Abbate, S. Subramanian, P. Yee, J. Gregorio, G. Teshima, G. Ott, S. Tuck, G. Van Nest, and R.L. Coffman.


Nucl. Acids Res., 2003; 31(17):5122-5133.

Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells.

Marshall, J.D., E.M. Hessel, J. Gregorio, C. Abbate, P. Yee, M. Chu, G.V. Nest, R.L. Coffman, and K.L. Fearon.


Blood, 2003; 102(13):4487-4492.

IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences.

Duramad, O., K.L. Fearon, J.H. Chan, H. Kanzler, J.D. Marshall, R.L. Coffman, and F.J. Barrat.


J. Immunol., 2004; 173(3):1647-1657.

CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells.

Teleshova, N., J. Kenney, J. Jones, J. Marshall, G. Van Nest, J. Dufour, R. Bohm, J.D. Lifson, A. Gettie, and M. Pope.


DNA Cell Biol., 2005; 24(2):63-72.

Superior Activity of the Type C Class of ISS In Vitro and In Vivo Across Multiple Species.

Marshall, J.D., K.L. Fearon, D. Higgins, E.M. Hessel, H. Kanzler, C. Abbate, P. Yee, J. Gregorio, T.D. Cruz, J.O. Lizcano, A. Zolotorev, H.M. McClure, K.M. Brasky, K.K. Murthy, R.L. Coffman, and G.V. Nest.


Immunity, 2005; 23:465-478.

Human TLR-7-, -8-, and -9-Mediated Induction of IFN-alpha/beta and -lambda is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses.

Kun Yang, Anne Puel, Shenying Zhang, Céline Eidenschenk, Cheng-Lung Ku, Armanda Casrouge, Capucine Picard, Horst von Bernuth, Brigitte Senechal, Sabine Plancoulaine, Sami Al-Hajjar, Abdulaziz Al-Ghonaium, László Maródi, Donald Davidson, David Speert, Chaim Roifman, Ben-Zion Garty, Adrian Ozinsky, Franck J. Barrat, Robert L. Coffman, Richard L. Miller, Xiaoxia Li, Pierre Lebon, Carlos Rodriguez-Gallego, Helen Chapel, Frédéric Geissmann, Emmanuelle Jouanguy, and Jean-Laurent Casanova.


J. Exp. Med., 2006; 203(8):1999-2008.

Properties Regulating the Nature of the Plasmacytoid Dendritic Cell Response to TLR9 Activation.

Cristiana Guiducci, Gary Ott, Jean H. Chan, Emily Damon, Carlo Calacsan, Tracy Matray, Kyung-Dall Lee, Robert L. Coffman and Franck J. Barrat.


Immunity, 2006; 25:665-664.

Toll-like Receptor Recognition Regulates Immunodominance in an Antimicrobial CD4+ T Cell Response.

Felix Yarovinsky, Holger Kanzler, Sara Hieny, Robert L. Coffman, and Alan Sher.