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Eur. J. Immunol., 2007; 37(12):3582-6.

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms.

Franck J. Barrat, Thea Meeker, Jean H. Chan, Cristiana Guiducci and Robert L. Coffman.


Immunological Reviews, 2008; 223:271-283.

Development of TLR inhibitors for the treatment of autoimmune diseases.

Frank J. Barrat and Robert L. Coffman.


Immunology Letters, 2008; 121:61–73.

Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: Involvement of HMGB1 in anti-DNA antibody-induced renal injury.

Xiaoping Qing, Milena Pitashny, David B. Thomas, Franck J. Barrat, Mark P. Hogarth, Chaim Putterman.


J. Intern. Med., 2008; 265:43-57.

Signalling pathways leading to IFN-a production in human PDC and the possible use of agonists or antagonists of TLR-7 and TLR-9 in clinical indications (Review).

Guiducci C, Coffman RL, Barrat FJ (Dynavax Technologies Corporation, Berkeley, CA USA).


J. Exp. Med., 2009; 206(9):1983-94.

Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

D. Ganguly, G. Chamilos, R. Lande, J. Gregorio, S. Meller, V. Facchinetti, B. Homey, F.J. Barrat, T. Zal, and M. Gilliet.


J. Immunol., 2010; 184(4):2148-55.

Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.

Clancy RM, Alvarez D, Komissarova E, Barrat FJ, Swartz J, Buyon JP.


Nature, 2010; 465(7300):937-41.

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, Chan JH, Wright T, Punaro M, Bolland S, Soumelis V, Banchereau J, Coffman RL, Pascual V, Barrat FJ.


J. Exp. Med., 2010; 207(13):2931-42.

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.

Guiducci C, Tripodo C, Gong M, Sangaletti S, Colombo MP, Coffman RL, Barrat FJ.


Sci. Transl. Med., 2011; 3(73):73ra20. PMCID: 3143837.

Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus.

Garcia-Romo GS, Caielli S, Vega B, Connolly J, Allantaz F, Xu Z, Punaro M, Baisch J, Guiducci C, Coffman RL, Barrat FJ, Banchereau J, Pascual V.


Allergy, 1997; 52:964-970.

DNA Immunization: A Novel Approach to Allergen-specific Immunotherapy.

Spiegelberg, H.L., E.M. Orozco, M. Roman, and E. Raz.