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J. Exp. Med., 2005; 202(11):1563-1573.

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.

Edith M. Hessel, Mabel Chu, Jennifer O. Lizcano, Bonnie Chang, Nancy Herman, Sariah A. Kell, Marsha Willis-Karp, and Robert L. Coffman.


J. Exp. Med., 2005; 201(12):1875–1879.

Nonhuman primate models of asthma.

Robert L. Coffman and Edith M. Hessel.


Am. J. Respir. Crit. Care Med., 2006; 174(1):15-20.

Immunostimulatory Sequences Regulate Interferon-inducible Genes but not Allergic Airway Responses.

Gail M Gauvreau, Edith M Hessel, Louis-Philippe Boulet, Robert L Coffman, and Paul M O'Byrne.


J. Allergy and Clin. Immunol., 2006; 118(2):504-10.

Modulation of immunogenicity and allergenicity by controlling the number of immunostimulatory oligonucleotides linked to Amb a 1.

Higgins, D., Rodriguez, R., Milley, R., Marshall, J., Abbate, C., dela Cruz, T., Patton, K., Walker, F., Chichester, K., Eiden, J., Tuck, S., Van Nest, G.


N. Engl. J. Med., 2006; 355(14):1445-55.

Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis.

Peter S. Creticos, M.D., John T. Schroeder, Ph.D., Robert G. Hamilton, Ph.D., Susan L. Balcer-Whaley, M.P.H., Arouna P. Khattignavong, M.D., Robert Lindblad, M.D., Henry Li, M.D., Ph.D., Robert Coffman, Ph.D., Vicki Seyfert, Ph.D., Joseph J. Eiden, M.D., Ph.D., David Broide, M.B., Ch.B., and the Immune Tolerance Network Group.


The American Journal of Medicine, 2006; 119(10):897.e1-6.

TLR9-Based Immunotherapy for Allergic Disease.

Tomoko Hayashi, MD, PhD, Eyal Raz, MD.


Clin. Exp. Allergy, 2010; 40(7):1025-35.

Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression.

Campbell JD, Buchmann P, Kesting S, Cunningham CR, Coffman RL, Hessel EM.


Thorax, 2014, Jan 24. doi: 10.1136/thoraxjnl-2013-204605

A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.

Campbell JD, Kell SA, Kozy HM, Lum JA, Sweetwood R, Chu M, Cunningham CR, Salamon H, Lloyd CM, Coffman RL, Hessel EM.


Nat. Immunol., 2006; 7(6):539-41.

Origins of the Th1-Th2 model: a personal perspective.

Robert L. Coffman.


Nature Medicine, 2007; 13(5):552-559.

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman.