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J. Immunol., 1998; 161:7054-7062.

Immunostimulatory DNA Sequences Inhibit IL-5, Eosinophilic Inflammation, and Airway Hyperresponsiveness in Mice.

Broide, D., J. Schwarze, H. Tighe, T. Gifford, M.D. Nguyen, S. Malek, J. Van Uden, E. Martin-Orozco, E.W. Gelfand, and E. Raz.


J. Allergy Clin. Immunol., 1999; 104:902-910.

Immunostimulatory DNA and Applications to Allergic Disease.

Van Uden, J. and E. Raz.


J. Allergy Clin. Immunol., 2002; 109:455-462.

Amb a 1-linked CpG Oligodeoxynucleotides Reverse Established Airway Hyperresponsiveness in a Murine Model of Asthma.

Santeliz, J.V., G. Van Nest, P. Traquina, E. Larsen, and M. Wills-Karp.


J. Allergy Clin. Immunol., 2004; 113(2):235-241.

Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response.

Tulic, M.K., P.O. Fiset, P. Christodoulopoulos, P. Vaillancourt, M. Desrosiers, F. Lavigne, J. Eiden, and Q. Hamid.


J. Exp. Med., 2005; 202(11):1563-1573.

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.

Edith M. Hessel, Mabel Chu, Jennifer O. Lizcano, Bonnie Chang, Nancy Herman, Sariah A. Kell, Marsha Willis-Karp, and Robert L. Coffman.


J. Exp. Med., 2005; 201(12):1875–1879.

Nonhuman primate models of asthma.

Robert L. Coffman and Edith M. Hessel.


Am. J. Respir. Crit. Care Med., 2006; 174(1):15-20.

Immunostimulatory Sequences Regulate Interferon-inducible Genes but not Allergic Airway Responses.

Gail M Gauvreau, Edith M Hessel, Louis-Philippe Boulet, Robert L Coffman, and Paul M O'Byrne.


J. Allergy and Clin. Immunol., 2006; 118(2):504-10.

Modulation of immunogenicity and allergenicity by controlling the number of immunostimulatory oligonucleotides linked to Amb a 1.

Higgins, D., Rodriguez, R., Milley, R., Marshall, J., Abbate, C., dela Cruz, T., Patton, K., Walker, F., Chichester, K., Eiden, J., Tuck, S., Van Nest, G.


N. Engl. J. Med., 2006; 355(14):1445-55.

Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis.

Peter S. Creticos, M.D., John T. Schroeder, Ph.D., Robert G. Hamilton, Ph.D., Susan L. Balcer-Whaley, M.P.H., Arouna P. Khattignavong, M.D., Robert Lindblad, M.D., Henry Li, M.D., Ph.D., Robert Coffman, Ph.D., Vicki Seyfert, Ph.D., Joseph J. Eiden, M.D., Ph.D., David Broide, M.B., Ch.B., and the Immune Tolerance Network Group.


The American Journal of Medicine, 2006; 119(10):897.e1-6.

TLR9-Based Immunotherapy for Allergic Disease.

Tomoko Hayashi, MD, PhD, Eyal Raz, MD.